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Colloquium Announcement on Apr. 24, 2017
W-Name Admin (IP: *.152.74.116) W-Date 2017-04-11 14:18 Hit 613

Title: Mechanisms of Prefrontal Gamma Oscillation

Speaker : Dr. Jee Hyun Choi (Center for Neuroscience, Korea Institute of Science and Technology

Department of Neural Sciences, University of Science and Technology)

Date: Apr. 24 (Mon.), 2017

Time: 05:00 PM 

Location: Woo Jung Information & Communication bldg., Room 601

Hosted by Dept. of Brain & Cognitive Engineering, Korea University / Institute of Brain and Cognitive Engineering, Korea University / BK21+ Global Leader Development Division in Brain Engineering, Korea University / Interdisciplinary Major in Brain and Cognitive Science


Cortical gamma oscillations (30 ~ 80 Hz) are crucial to consciousness, attention, perception, and memory formation, and failure in gamma regulation is a hallmark of neurological and psychiatric disease. Recent studies using optogenetics have shown that gamma oscillations are induced by selective activation of fast-spiking interneurons containing calcium-binding protein parvalbumin (PV) and the subcortical PV cells, particularly cortex projecting PV cells in basal forebrain (BF-PV cells), are responsible to trigger the cortical gamma band oscillation. However, the cortical regions in the gamma oscillation reign of BF-PV cells are not known. Here, we combined the optogenetic interrogation with high density EEG in freely moving mice to detmine the spatio-frequency characteristics of cortical gamma band oscillation driven by BF-PV cells. We found that gamma band oscillation of BF-PV cells induced cortical gamma oscillation in the frontal cortex, whereas slow oscillation of these neurons induced diffusive and variant cortical activation mostly in the centro-parietal cortex. We further applied pulse train sound locking to the optogenetic stimulation. An in-phase activation of BF-PV cells lead more phasic response to the auditory sound, whereas out-of-phase activation suppressed the auditory evoked frontal responses. Thus, these findings indicate that BF-PV cells generate the frontal gamma oscillation and may be involved in their functional role.

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