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Colloquium Announcement on Mar. 19, 2018
W-Name Admin (IP: *.152.74.116) W-Date 2018-03-12 14:22 Hit 372

Multifunctional MEMS Neural Probe for In-vivo and In-vitro applications

Speaker : Dr. Il-Joo Cho (Centre for BioMicrosystems, Brain Science Institute, KIST)

Date: Mar. 19 (Mon.), 2018

Time: 05:00 PM 

Location: Woo Jung Information & Communication bldg., Room 601

Hosted by Dept. of Brain & Cognitive Engineering, Korea University / Institute of Brain and Cognitive Engineering, Korea University / BK21+ Global Leader Development Division in Brain Engineering, Korea University / Interdisciplinary Major in Brain and Cognitive Science


MEMS neural probes have shown promising results in studying the central nervous system at the cellular level. Conventional electrical stimulation not only induces damages neurons but also suffers from poor spatial resolution, since the necessary electrical fields extend across large areas rather than individual neurons. To solve these problems, an optical stimulation method has been introduced, and showed better results, using an optical fiber attached to the probe shank as the optical source. To investigate and modulate the long-range neuronal circuits, neural probe array with various stimulation capabilities such as optical stimulation and chemical stimulation are required. We present a monolithically integrated multi-functional MEMS neural probe array by integrating both an embedded microfluidic channel for drug delivery and an SU-8 optical waveguide for optical stimulation. We also demonstrate a successful in-vivo optical stimulation and recording of neural signals from the hippocampus of a transgenic ChR2-YFP mouse. In addition to the optical stimulation capability, the integrated microfluidic channel gives a way to deliver drug or virus into deep brain regions. Using our multifunctional neural probe, we confirmed the connectivity between CA1 and CA3 of the hippocampus region of a mouse in-vivo and modulated the neuronal circuit. Also, we recently demonstrated that the neural probe system can modulate neural circuits implemented in a 3D cell-culture platform.

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