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Research
Prof. Heung-Il Suk's paper accepted in NeuroImage
Author Administrator (IP: *.152.74.116) Date 2019-08-20 10:33 Views 481
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Prof. Heung-Il Suk's research paper, 'Toward an Interpretable Alzheimer's Disease Diagnostic Model with Regional Abnormality Representation via Deep Learning' was accepted in NeuroImage.

 

 

Title: Toward an Interpretable Alzheimer's Disease Diagnostic Model with Regional Abnormality Representation via Deep Learning 

 

Abstract: In this paper, we propose a novel method for magnetic resonance imaging based Alzheimer's disease (AD) or mild cognitive impairment (MCI) diagnosis that systematically integrates voxel-based, region-based, and patch-based approaches into a unified framework. Specifically, we parcellate the brain into predefined regions based on anatomical knowledge (i.e., templates) and derive complex nonlinear relationships among voxels, whose intensities denote volumetric measurements, within each region. Unlike existing methods that use cubical or rectangular shapes, we consider the anatomical shapes of regions as atypical patches. Using complex nonlinear relationships among voxels in each region learned by deep neural networks, we extract a "regional abnormality representation." We then make a final clinical decision by integrating the regional abnormality representations over the entire brain. It is noteworthy that the regional abnormality representations allow us to interpret and understand the symptomatic observations of a subject with AD or MCI by mapping and visualizing these observations in the brain space. On the baseline MRI dataset from the Alzheimer's Disease Neuroimaging Initiative (ADNI) cohort, our method achieves state-of-the-art performance for four binary classification tasks and one three-class classification task. Additionally, we conducted exhaustive experiments and analysis to validate the efficacy and potential of our method. 

 

Journal: NeuroImage (2018-JCR-IF: 5.812, NEUROIMAGING: 1/14, RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING: 11/129)


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Research
Prof. Byoung-Kyong Min's paper published at NeuroImage
Prof. Byoung-Kyong Min's paper published at NeuroImage
Prof. Byoung-Kyong Min's research paper, 'Thalamocortical Inhibitory Dynamics Support Conscious Perception' was publishsed at NeuroImage. Link to the publication: https://doi.org/10.1016/j.neuroimage.2020.117066 Title: Thalamocortical Inhibitory Dynamics Support Conscious Perception Abstract:Whether thalamocortical interactions play a decisive role in conscious perception remains an open question. We presented rapid red/g…

2020-06-15

Prof. Jeehyun Kwag's paper accepted in Chaos
Prof. Jeehyun Kwag's paper accepted in Chaos
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2020-05-29

Prof. Jeehyun Kwag's paper accepted in Science Advances
Prof. Jeehyun Kwag's paper accepted in Science Advances
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2020-04-23

Prof. Byoung-Kyong Min's paper accepted in Trends in Biotechnology
Prof. Byoung-Kyong Min's paper accepted in Trends in Biotechnology
Prof. Byoung-Kyong Min's research paper, 'New Cognitive Neurotechnology Facilitates Studies of Cortical-Subcortical Interactions' was accepted in Trends in Biotechnology. Title: New Cognitive Neurotechnology Facilitates Studies of Cortical-Subcortical Interactions Abstract:Most of the studies employing neuroimaging have focused on cortical and subcortical signals individually to obtain neurophysiological signatures of cognitiv…

2020-03-09

Prof. Jeehyun Kwag's paper accepted in Brain Structure and Function
Prof. Jeehyun Kwag's paper accepted in Brain Structure and Function
Prof. Jeehyun Kwag's research paper, 'Dissociation of Somatostatin and Parvalbumin Interneurons Circuit Dysfunctions Underlying Hippocampal Theta and Gamma Oscillations impaired by Amyloid β Oligomers in Vivo' was accepted in Brain Structure and Function. Publication Link: https://link.springer.com/article/10.1007/s00429-020-02044-3Title: Dissociation of somatostatin and parvalbumin interneurons circuit dysfunctions underlyin…

2020-03-02

Prof. Jeehyun Kwag's paper accepted in BMC Biology
Prof. Jeehyun Kwag's paper accepted in BMC Biology
Prof. Jeehyun Kwag's research paper, 'Optogenetic activation of parvalbumin and somatostatin interneurons selectively restores theta-nested gamma oscillations and oscillation-induced spike timing-dependent long-term potentiation impaired by amyloid β oligomers' was accepted in BMC Biology. Title: Optogenetic activation of parvalbumin and somatostatin interneurons selectively restores theta-nested gamma oscillations and oscillation…

2020-03-02

Prof. Heung-Il Suk's paper accepted in NeuroImage
Prof. Heung-Il Suk's paper accepted in NeuroImage
Prof. Heung-Il Suk's research paper, 'Toward an Interpretable Alzheimer's Disease Diagnostic Model with Regional Abnormality Representation via Deep Learning' was accepted in NeuroImage.  Title: Toward an Interpretable Alzheimer's Disease Diagnostic Model with Regional Abnormality Representation via Deep Learning  Abstract: In this paper, we propose a novel method for magnetic resonance imaging based Alzheimer's disease (…

2019-08-20

Prof.Jae-Ho Han’s paper accepted in IEEE Transactions on Image Processing
Prof.Jae-Ho Han’s paper accepted in IEEE Transactions on Image Processing
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2019-07-24

Prof. Seong-Whan Lee's paper accepted in IEEE Transactions on Intelligent Transportation Systems
Prof. Seong-Whan Lee's paper accepted in IEEE Transactions on Intelligent Transp…
Prof. Seong-Whan Lee's new research, Coarse-to-Fine Deep Learning of Continuous Pedestrian Orientation Based on Spatial Co-occurrence Feature was accepted in IEEE Transactions on Intelligent Transportation Systems. Title: 'Coarse-to-Fine Deep Learning of Continuous Pedestrian Orientation Based on Spatial Co-occurrence Feature Abstract: The continuous orientation estimation of a moving pedestrian is a crucial issue in auto…

2019-05-02

Prof. Heung-Il Suk's paper accepted in Neural Networks
Prof. Heung-Il Suk's paper accepted in Neural Networks
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2019-03-07

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