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Research
Prof. Jeehyun Kwag's paper accepted in BMC Biology
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Prof. Jeehyun Kwag's research paper, 'Optogenetic activation of parvalbumin and somatostatin interneurons selectively restores theta-nested gamma oscillations and oscillation-induced spike timing-dependent long-term potentiation impaired by amyloid β oligomers' was accepted in BMC Biology.

 

Title: Optogenetic activation of parvalbumin and somatostatin interneurons selectively restores theta-nested gamma oscillations and oscillation-induced spike timing-dependent long-term potentiation impaired by amyloid β oligomers
 
Abstract: 

Abnormal accumulation of amyloid β1–42 oligomers (AβO1–42), a hallmark of Alzheimer’s disease, impairs hippocampal theta-nested gamma oscillations and long-term potentiation (LTP) that are believed to underlie learning and memory. Parvalbumin-positive (PV) and somatostatin-positive (SST) interneurons are critically involved in theta-nested gamma oscillogenesis and LTP induction. However, how AβO1–42 affects PV and SST interneuron circuits is unclear. Through optogenetic manipulation of PV and SST interneurons and computational modeling of the hippocampal neural circuits, we dissected the contributions of PV and SST interneuron circuit dysfunctions on AβO1–42-induced impairments of hippocampal theta-nested gamma oscillations and oscillation-induced LTP. Targeted whole-cell patch-clamp recordings and optogenetic manipulations of PV and SST interneurons during in vivo-like, optogenetically induced theta-nested gamma oscillations in vitro revealed that AβO1–42 causes synapse-specific dysfunction in PV and SST interneurons. AβO1–42 selectively disrupted CA1 pyramidal cells (PC)-to-PV interneuron and PV-to-PC synapses to impair theta-nested gamma oscillogenesis. In contrast, while having no effect on PC-to-SST or SST-to-PC synapses, AβO1–42 selectively disrupted SST interneuron-mediated disinhibition to CA1 PC to impair theta-nested gamma oscillation-induced spike timing-dependent LTP (tLTP). Such AβO1–42-induced impairments of gamma oscillogenesis and oscillation-induced tLTP were fully restored by optogenetic activation of PV and SST interneurons, respectively, further supporting synapse-specific dysfunctions in PV and SST interneurons. Finally, computational modeling of hippocampal neural circuits including CA1 PC, PV, and SST interneurons confirmed the experimental observations and further revealed distinct functional roles of PV and SST interneurons in theta-nested gamma oscillations and tLTP induction. Our results reveal that AβO1–42 causes synapse-specific dysfunctions in PV and SST interneurons and that optogenetic modulations of these interneurons present potential therapeutic targets for restoring hippocampal network oscillations and synaptic plasticity impairments in Alzheimer’s disease.

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Research
Prof. Heung-Il Suk's paper. selected as Most Downloaded Article in the Past Year
Prof. Heung-Il Suk's paper. selected as Most Downloaded Article in the Past Year
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2020-08-03

Prof. Byoung-Kyong Min's paper published at NeuroImage
Prof. Byoung-Kyong Min's paper published at NeuroImage
Prof. Byoung-Kyong Min's research paper, 'Thalamocortical Inhibitory Dynamics Support Conscious Perception' was publishsed at NeuroImage. Link to the publication: https://doi.org/10.1016/j.neuroimage.2020.117066 Title: Thalamocortical Inhibitory Dynamics Support Conscious Perception Abstract:Whether thalamocortical interactions play a decisive role in conscious perception remains an open question. We presented rapid red/g…

2020-06-15

Prof. Jeehyun Kwag's paper accepted in Chaos
Prof. Jeehyun Kwag's paper accepted in Chaos
Prof. Jeehyun Kwag's research paper, 'Distinct subtypes of inhibitory interneurons differentially promote the propagation of rate and temporal codes in the feedforward neural network' was accepted in Chaos.  link to the publication: https://aip.scitation.org/doi/full/10.1063/1.5134765Title: Distinct subtypes of inhibitory interneurons differentially promote the propagation of rate and temporal codes in the feedforward neu…

2020-05-29

Prof. Jeehyun Kwag's paper accepted in Science Advances
Prof. Jeehyun Kwag's paper accepted in Science Advances
Prof. Jeehyun Kwag's research paper, 'Distinct roles of parvalbumin and somatostatin interneurons in gating the synchronization of spike times in the neocortex'  was accepted in Science Advances.  Publication Link: https://advances.sciencemag.org/content/6/17/eaay5333/Title: Distinct roles of parvalbumin and somatostatin interneurons in gating the synchronization of spike times in the neocortexAbstract: Synchron…

2020-04-23

Prof. Byoung-Kyong Min's paper accepted in Trends in Biotechnology
Prof. Byoung-Kyong Min's paper accepted in Trends in Biotechnology
Prof. Byoung-Kyong Min's research paper, 'New Cognitive Neurotechnology Facilitates Studies of Cortical-Subcortical Interactions' was accepted in Trends in Biotechnology. Title: New Cognitive Neurotechnology Facilitates Studies of Cortical-Subcortical Interactions Abstract:Most of the studies employing neuroimaging have focused on cortical and subcortical signals individually to obtain neurophysiological signatures of cognitiv…

2020-03-09

Prof. Jeehyun Kwag's paper accepted in Brain Structure and Function
Prof. Jeehyun Kwag's paper accepted in Brain Structure and Function
Prof. Jeehyun Kwag's research paper, 'Dissociation of Somatostatin and Parvalbumin Interneurons Circuit Dysfunctions Underlying Hippocampal Theta and Gamma Oscillations impaired by Amyloid β Oligomers in Vivo' was accepted in Brain Structure and Function. Publication Link: https://link.springer.com/article/10.1007/s00429-020-02044-3Title: Dissociation of somatostatin and parvalbumin interneurons circuit dysfunctions underlyin…

2020-03-02

Prof. Jeehyun Kwag's paper accepted in BMC Biology
Prof. Jeehyun Kwag's paper accepted in BMC Biology
Prof. Jeehyun Kwag's research paper, 'Optogenetic activation of parvalbumin and somatostatin interneurons selectively restores theta-nested gamma oscillations and oscillation-induced spike timing-dependent long-term potentiation impaired by amyloid β oligomers' was accepted in BMC Biology. Title: Optogenetic activation of parvalbumin and somatostatin interneurons selectively restores theta-nested gamma oscillations and oscillation…

2020-03-02

Prof. Heung-Il Suk's paper accepted in NeuroImage
Prof. Heung-Il Suk's paper accepted in NeuroImage
Prof. Heung-Il Suk's research paper, 'Toward an Interpretable Alzheimer's Disease Diagnostic Model with Regional Abnormality Representation via Deep Learning' was accepted in NeuroImage.  Title: Toward an Interpretable Alzheimer's Disease Diagnostic Model with Regional Abnormality Representation via Deep Learning  Abstract: In this paper, we propose a novel method for magnetic resonance imaging based Alzheimer's disease (…

2019-08-20

Prof.Jae-Ho Han’s paper accepted in IEEE Transactions on Image Processing
Prof.Jae-Ho Han’s paper accepted in IEEE Transactions on Image Processing
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2019-07-24

Prof. Seong-Whan Lee's paper accepted in IEEE Transactions on Intelligent Transportation Systems
Prof. Seong-Whan Lee's paper accepted in IEEE Transactions on Intelligent Transp…
Prof. Seong-Whan Lee's new research, Coarse-to-Fine Deep Learning of Continuous Pedestrian Orientation Based on Spatial Co-occurrence Feature was accepted in IEEE Transactions on Intelligent Transportation Systems. Title: 'Coarse-to-Fine Deep Learning of Continuous Pedestrian Orientation Based on Spatial Co-occurrence Feature Abstract: The continuous orientation estimation of a moving pedestrian is a crucial issue in auto…

2019-05-02

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