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Prof. Jeehyun Kwag's paper accepted in Brain Structure and Function
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Prof. Jeehyun Kwag's research paper, 'Dissociation of Somatostatin and Parvalbumin Interneurons Circuit Dysfunctions Underlying Hippocampal Theta and Gamma Oscillations impaired by Amyloid β Oligomers in Vivo' was accepted in Brain Structure and Function.

 


Title: Dissociation of somatostatin and parvalbumin interneurons circuit dysfunctions underlying hippocampal theta and gamma oscillations impaired by amyloid β oligomers in vivo 

Abstract: 
Accumulation of amyloid β oligomers (AβO) in Alzheimer’s disease (AD) impairs hippocampal theta and gamma oscillations. These oscillations are important in memory functions and depend on distinct subtypes of hippocampal interneurons such as somatostatin-positive (SST) and parvalbumin-positive (PV) interneurons. Here, we investigated whether AβO causes dysfunctions in SST and PV interneurons by optogenetically manipulating them during theta and gamma oscillations in vivo in AβO-injected SST-Cre or PV-Cre mice. Hippocampal in vivo multi-electrode recordings revealed that optogenetic activation of channelrhodopsin-2 (ChR2)-expressing SST and PV interneurons in AβO-injected mice selectively restored AβO-induced reduction of the peak power of theta and gamma oscillations, respectively, and resynchronized CA1 pyramidal cell (PC) spikes. Moreover, SST and PV interneuron spike phases were resynchronized relative to theta and gamma oscillations, respectively. Whole-cell voltage-clamp recordings in CA1 PC in ex vivo hippocampal slices from AβO-injected mice revealed that optogenetic activation of SST and PV interneurons enhanced spontaneous inhibitory postsynaptic currents (IPSCs) selectively at theta and gamma frequencies, respectively. Furthermore, analyses of the stimulus–response curve, paired-pulse ratio, and short-term plasticity of SST and PV interneuron-evoked IPSCs ex vivo showed that AβO increased the initial GABA release probability to depress SST/PV interneuron’s inhibitory input to CA1 PC selectively at theta and gamma frequencies, respectively. Our results reveal frequency-specific and interneuron subtype-specific presynaptic dysfunctions of SST and PV interneurons’ input to CA1 PC as the synaptic mechanisms underlying AβO-induced impairments of hippocampal network oscillations and identify them as potential therapeutic targets for restoring hippocampal network oscillations in early AD.



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Research
Prof. Heung-Il Suk's paper. selected as Most Downloaded Article in the Past Year
Prof. Heung-Il Suk's paper. selected as Most Downloaded Article in the Past Year
 Prof. Heung-Il Suk's paper on "Deep Learning in Medical Image Analysis" was selected as "Most Downloaded Article in the Past Year" in the Annual Review of Biomedical Engineering (2019-JCR-IF: 15.541). Please refer to the link for more information. https://www.annualreviews.org/journal/bioeng

2020-08-03

Prof. Byoung-Kyong Min's paper published at NeuroImage
Prof. Byoung-Kyong Min's paper published at NeuroImage
Prof. Byoung-Kyong Min's research paper, 'Thalamocortical Inhibitory Dynamics Support Conscious Perception' was publishsed at NeuroImage. Link to the publication: https://doi.org/10.1016/j.neuroimage.2020.117066 Title: Thalamocortical Inhibitory Dynamics Support Conscious Perception Abstract:Whether thalamocortical interactions play a decisive role in conscious perception remains an open question. We presented rapid red/g…

2020-06-15

Prof. Jeehyun Kwag's paper accepted in Chaos
Prof. Jeehyun Kwag's paper accepted in Chaos
Prof. Jeehyun Kwag's research paper, 'Distinct subtypes of inhibitory interneurons differentially promote the propagation of rate and temporal codes in the feedforward neural network' was accepted in Chaos.  link to the publication: https://aip.scitation.org/doi/full/10.1063/1.5134765Title: Distinct subtypes of inhibitory interneurons differentially promote the propagation of rate and temporal codes in the feedforward neu…

2020-05-29

Prof. Jeehyun Kwag's paper accepted in Science Advances
Prof. Jeehyun Kwag's paper accepted in Science Advances
Prof. Jeehyun Kwag's research paper, 'Distinct roles of parvalbumin and somatostatin interneurons in gating the synchronization of spike times in the neocortex'  was accepted in Science Advances.  Publication Link: https://advances.sciencemag.org/content/6/17/eaay5333/Title: Distinct roles of parvalbumin and somatostatin interneurons in gating the synchronization of spike times in the neocortexAbstract: Synchron…

2020-04-23

Prof. Byoung-Kyong Min's paper accepted in Trends in Biotechnology
Prof. Byoung-Kyong Min's paper accepted in Trends in Biotechnology
Prof. Byoung-Kyong Min's research paper, 'New Cognitive Neurotechnology Facilitates Studies of Cortical-Subcortical Interactions' was accepted in Trends in Biotechnology. Title: New Cognitive Neurotechnology Facilitates Studies of Cortical-Subcortical Interactions Abstract:Most of the studies employing neuroimaging have focused on cortical and subcortical signals individually to obtain neurophysiological signatures of cognitiv…

2020-03-09

Prof. Jeehyun Kwag's paper accepted in Brain Structure and Function
Prof. Jeehyun Kwag's paper accepted in Brain Structure and Function
Prof. Jeehyun Kwag's research paper, 'Dissociation of Somatostatin and Parvalbumin Interneurons Circuit Dysfunctions Underlying Hippocampal Theta and Gamma Oscillations impaired by Amyloid β Oligomers in Vivo' was accepted in Brain Structure and Function. Publication Link: https://link.springer.com/article/10.1007/s00429-020-02044-3Title: Dissociation of somatostatin and parvalbumin interneurons circuit dysfunctions underlyin…

2020-03-02

Prof. Jeehyun Kwag's paper accepted in BMC Biology
Prof. Jeehyun Kwag's paper accepted in BMC Biology
Prof. Jeehyun Kwag's research paper, 'Optogenetic activation of parvalbumin and somatostatin interneurons selectively restores theta-nested gamma oscillations and oscillation-induced spike timing-dependent long-term potentiation impaired by amyloid β oligomers' was accepted in BMC Biology. Title: Optogenetic activation of parvalbumin and somatostatin interneurons selectively restores theta-nested gamma oscillations and oscillation…

2020-03-02

Prof. Heung-Il Suk's paper accepted in NeuroImage
Prof. Heung-Il Suk's paper accepted in NeuroImage
Prof. Heung-Il Suk's research paper, 'Toward an Interpretable Alzheimer's Disease Diagnostic Model with Regional Abnormality Representation via Deep Learning' was accepted in NeuroImage.  Title: Toward an Interpretable Alzheimer's Disease Diagnostic Model with Regional Abnormality Representation via Deep Learning  Abstract: In this paper, we propose a novel method for magnetic resonance imaging based Alzheimer's disease (…

2019-08-20

Prof.Jae-Ho Han’s paper accepted in IEEE Transactions on Image Processing
Prof.Jae-Ho Han’s paper accepted in IEEE Transactions on Image Processing
Prof. Jae-Ho Han’s new research on `Deep Neural Network Regression for Automated Retinal Layer Segmentation in Optical Coherence Tomography Images` was accepted in IEEE Transactions on Image Processing.  Title: Deep Neural Network Regression for Automated Retinal Layer Segmentation in Optical Coherence Tomography ImagesAbstract: Segmenting the retinal layers in optical coherence tomography (OCT) images helps to quantify the …

2019-07-24

Prof. Seong-Whan Lee's paper accepted in IEEE Transactions on Intelligent Transportation Systems
Prof. Seong-Whan Lee's paper accepted in IEEE Transactions on Intelligent Transp…
Prof. Seong-Whan Lee's new research, Coarse-to-Fine Deep Learning of Continuous Pedestrian Orientation Based on Spatial Co-occurrence Feature was accepted in IEEE Transactions on Intelligent Transportation Systems. Title: 'Coarse-to-Fine Deep Learning of Continuous Pedestrian Orientation Based on Spatial Co-occurrence Feature Abstract: The continuous orientation estimation of a moving pedestrian is a crucial issue in auto…

2019-05-02

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